Jimmy Kimmel — decked out as Rosie O’Donnell   — tells the ladies of The View that Sarah Silverman is done dating an “imbecile.”

One of America’s funniest couples is calling it quits…again.

Jimmy Kimmel and Sarah Silverman have broken up for a second time, a source confirmed to US Weekly.

Kimmel and Silverman began dating six years ago. The pair reunited in October, after announcing their first split in July.

A source tells the mag it was Sarah who initiated the split this time, and Jimmy is “bummed.”

“He’s really blue — very down,” another source added. “Seems like it’s over for good this time. He’s sad because he just bought a new place and now has nobody to share it with.”

The couple first met during a roast for Hugh Hefner.

It looks like Jimmy Kimmel and Sarah Silverman are back together.

“They’re taking it slow,” a source tells People magazine. “They’re on the road back to being together again.”

The pair – who dated for five years before breaking up in July – were spotted together this weekend at pal Howard Stern’s wedding.

Kimmel, 40, and Silverman, 37, also shared dinner together in L.A. on Sept. 28.

So are they or aren’t they officially a couple again?

For her part, Silverman isn’t saying.

“We talk every day. It’s fine, it’s great,” she tells Tuesday’s New York Times. “I’m doing his show at the end of the month. We’re very Demi and Bruce.”

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It’s no joke, Sarah Silverman is not about to make fun of her recent breakup with fellow funnyman Jimmy Kimmel.

“Did someone tell you I’m going through a hard time?” Silverman, 37, said during a comedy show at West Hollywood’s Largo at the Coronet.

That was the first and last comment she’s made since the pair called it quits earlier this month.

The comedian, who earned an Emmy nomination for her spoof music video targeting then-boyfriend Kimmel “I’m F***ing Matt Damon,” avoided relationship jokes in general.

During the 15-minute set, Silverman included jokes on Barack Obama, Kanye West and talked about her TV show, The Sarah Silverman Project.

Silverman and Kimmel dated for five years before their split.

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